Intensivmedizin up2date, Table of Contents Intensivmedizin up2date 2016; 12(02): 139-155DOI: 10.1055/s-0041-111756 Allgemeine Prinzipien der Intensivmedizin © Georg Thieme Verlag KG Stuttgart · New YorkVenovenöse extrakorporale Membranoxygenierung Authors Axel Schmutz Christoph Benk Tobias Wengenmayer Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Full Text References Literatur 1 Extracorporeal Life Support Organization. ELSO Adult Respiratory Failure Supplement to the ELSO General Guidelines. Version 1.3 December 2013. Im Internet: http://www.elso.org/Portals/0/IGD/Archive/FileManager/989d4d4d14cusersshyerdocumentselsoguidelinesforadultrespiratoryfailure1.3.pdf [Stand: 20.04.2015] 2 Hill JD, O’Brien TG, Murray JJ et al. Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome). Use of the Bramson membrane lung. N Engl J Med 1972; 286: 629-634 3 Allison PL, Kurusz M, Graves DF et al. Devices and monitoring during neonatal ECMO: survey results. Perfusion 1990; 5: 193-201 4 Peek GJ, Mugford M, Tiruvoipati R et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 2009; 374: 1351-1363 5 Sauer CM, Yuh DD, Bonde P. Extracorporeal membrane oxygenation use has increased by 433% in adults in the United States from 2006 to 2011. ASAIO Journal 2015; 61: 31-36 6 Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med 2011; 365: 1905-1914 7 Guérin C, Reignier J, Richard J et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013; 368: 2159-2168 8 Shekar K, Davies AR, Mullany DV et al. To ventilate, oscillate, or cannulate?. J Crit Care 2013; 28: 655-662 9 Pham T, Combes A, Rozé H et al. Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis. AJRCCM 2013; 187: 276-285 10 Kok J, Blyth CC, Foo H et al. Viral pneumonitis is increased in obese patients during the first wave of pandemic A(H1N1) 2009 virus. PloS one 2013; 8: e55631 11 Extracorporeal Life Support Organization. ELSO Patient Specific Supplements to the ELSO General Guidelines Version December 2013. Im Internet: https://www.elso.org/Portals/0/IGD/Archive/FileManager/989d4d4d14cusersshyerdocumentselsoguidelinesforadultrespiratoryfailure1.3.pdf [Stand: 02.04.2015] 12 Murray JF, Matthay MA, Luce JM et al. An expanded definition of the adult respiratory distress syndrome. The American review of respiratory disease 1988; 138: 720-723 13 Esteban A, Fernández-Segoviano P, Frutos-Vivar F et al. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Int Med 2004; 141: 440-445 14 Ranieri VM, Rubenfeld GD, Thompson BT et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012; 307: 2526-2533 15 Ferguson ND, Fan E, Camporota L et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Int Care Med 2012; 38: 1573-1582 16 Thompson BT, Matthay MA. The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage. AJRCCM 2013; 187: 675-677 17 Thille AW, Esteban A, Fernández-Segoviano P et al. Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy. AJRCCM 2013; 187: 761-767 18 Bein T, Weber-Carstens S, Goldmann A et al. Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‛conventional’ protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study. Int Care Med 2013; 39: 847-856 19 Cove ME, MacLaren G, Federspiel WJ et al. Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Critical care (London, England) 2012; 16: 232 20 Terragni P, Maiolo G, Ranieri VM. Role and potentials of low-flow CO(2) removal system in mechanical ventilation. Current opinion in critical care 2012; 18: 93-98 21 Müller T, Bein T, Philipp A et al. Extracorporeal pulmonary support in severe pulmonary failure in adults: a treatment rediscovered. Dtsch Arztebl international 2013; 110: 159-166 22 Schmid C, Philipp A, Hilker M et al. Venovenous extracorporeal membrane oxygenation for acute lung failure in adults. Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation 2012; 31: 9-15 23 Chalwin RP, Moran JL, Graham PL. The role of extracorporeal membrane oxygenation for treatment of the adult respiratory distress syndrome: review and quantitative analysis. Anesthesia and intensive care 2008; 36: 152-161 24 Morris AH, Wallace CJ, Menlove RL et al. Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. AJRCCM 1994; 149: 295-305 25 Zapol WM, Snider MT, Hill JD et al. Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA 1979; 242: 2193-2196 26 Davies A, Jones D, Bailey M et al. Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA 2009; 302: 1888-1895 27 Gattinoni L, Carlesso E, Langer T. Clinical review: Extracorporeal membrane oxygenation. Critical Care (London, England) 2011; 15: 243 28 Sidebotham D, McGeorge A, McGuinness S et al. Extracorporeal membrane oxygenation for treating severe cardiac and respiratory disease in adults: Part 1 – overview of extracorporeal membrane oxygenation. Journal of cardiothoracic and vascular anesthesia 2009; 23: 886-892 29 Zampieri FG, Mendes PV, Ranzani OT et al. Extracorporeal membrane oxygenation for severe respiratory failure in adult patients: a systematic review and meta-analysis of current evidence. J Crit Care 2013; 28: 998-1005 30 Tramm R, Ilic D, Davies AR et al. Extracorporeal membrane oxygenation for critically ill adults. The Cochrane database of systematic reviews 2015; 1: CD010381 31 EOLIA Trial. NCT01470703. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome (EOLIA). Im Internet: http://clinicaltrials.gov/ct2/show/NCT01470703 [Stand: 30.03.2015] 32 SUPERNOVA-Trial. NCT02282657 Strategy of UltraProtective Lung Ventilation With Extracorporeal CO2 Removal for New-Onset Moderate to seVere ARDS: SUPERNOVA. Im Internet: https://clinicaltrials.gov/ct2/show/NCT02282657 [Stand: 30.03.2015] 33 Lang G, Kim D, Aigner C et al. Awake extracorporeal membrane oxygenation bridging for pulmonary retransplantation provides comparable results to elective retransplantation. Journal of Heart and Lung Transplantation 2014; 33: 1264-1272 34 Brogan TV, Thiagarajan RR, Rycus PT et al. Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database. Int Care Med 2009; 35: 2105-2114 35 Rosenberg AA, Haft JW, Bartlett R et al. Prolonged duration ECMO for ARDS: futility, native lung recovery, or transplantation?. ASAIO Journal 2013; 59: 642-650 36 Wiktor AJ, Haft JW, Bartlett RH et al. Prolonged VV ECMO (265 Days) for ARDS without technical complications. ASAIO Journal 2015; 61: 205-206 37 The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308 38 Bein T, Zimmermann M, Hergeth K et al. Pumpless extracorporeal removal of carbon dioxide combined with ventilation using low tidal volume and high positive end-expiratory pressure in a patient with severe acute respiratory distress syndrome. Anesthesia 2009; 64: 195-198 39 Mauri T, Foti G, Zanella A et al. Long-term extracorporeal membrane oxygenation with minimal ventilatory support: a new paradigm for severe ARDS?. Minerva Anestesiologica 2012; 78: 385-389 40 Marhong JD, Telesnicki T, Munshi L et al. Mechanical ventilation during extracorporeal membrane oxygenation. An international survey. Annals of the American Thoracic Society 2014; 11: 956-961 41 MacLaren G, Combes A, Bartlett RH. Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era. Int Care Med 2012; 38: 210-220 42 Terragni PP, Rosboch G, Tealdi A et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. AJRCCM 2007; 175: 160-166 43 Caironi P, Cressoni M, Chiumello D et al. Lung opening and closing during ventilation of acute respiratory distress syndrome. AJRCCM 2010; 181: 578-586 44 Aboab J, Jonson B, Kouatchet A et al. Effect of inspired oxygen fraction on alveolar derecruitment in acute respiratory distress syndrome. Int Care Med 2006; 32: 1979-1986 45 Kallet RH, Matthay MA. Hyperoxic acute lung injury. Respiratory care 2013; 58: 123-141 46 Schmidt M, Pellegrino V, Combes A et al. Mechanical ventilation during extracorporeal membrane oxygenation. Critical Care (London, England) 2014; 18: 203 47 Dembinski R, Hochhausen N, Terbeck S et al. Pumpless extracorporeal lung assist for protective mechanical ventilation in experimental lung injury. Crit Care Med 2007; 35: 2359-2366 48 Grasso S, Stripoli T, Sacchi M et al. Inhomogeneity of lung parenchyma during the open lung strategy: a computed tomography scan study. AJRCCM 2009; 180: 415-423 49 Combes A, Bacchetta M, Brodie D et al. Extracorporeal membrane oxygenation for respiratory failure in adults. Current Opinion in Critical Care 2012; 18: 99-104 50 Levine S, Nguyen T, Taylor N et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008; 358: 1327-1335 51 Jaber S, Jung B, Matecki S et al. Clinical review: ventilator-induced diaphragmatic dysfunction – human studies confirm animal model findings!. Critical Care (London, England) 2011; 15: 206 52 Mauri T, Bellani G, Grasselli G et al. Patient-ventilator interaction in ARDS patients with extremely low compliance undergoing ECMO: a novel approach based on diaphragm electrical activity. Int Care Med 2013; 39: 282-291 53 Karagiannidis C, Lubnow M, Philipp A et al. Autoregulation of ventilation with neurally adjusted ventilatory assist on extracorporeal lung support. Int Care Med 2010; 36: 2038-2044 54 Yoshida T, Rinka H, Kaji A et al. The impact of spontaneous ventilation on distribution of lung aeration in patients with acute respiratory distress syndrome: airway pressure release ventilation versus pressure support ventilation. Anesthesia and Analgesia 2009; 109: 1892-1900 55 Del Sorbo L, Goffi A, Goligher E et al. Setting mechanical ventilation in ARDS patients during VV-ECMO: where are we?. Minerva Anestesiologica 2015; 81: 1369-1376 56 Extracorporeal Life Support Organization. Endotracheal extubation in patients with respiratory failure receiving venovenous ECMO. 2015 Im Internet: https://www.elso.org/Portals/0/Files/ELSO_ExtubationGuidelines_May2015.pdf [Stand: 20.06.2015] 57 Lehle K, Philipp A, Müller T et al. Flow dynamics of different adult ECMO systems: a clinical evaluation. Artificial Organs 2014; 38: 391-398 58 Wiedemann HP, Wheeler AP, Bernard GR et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006; 354: 2564-2575 59 Schmidt M, Bailey M, Kelly J et al. Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation. Int Care Med 2014; 40: 1256-1266 60 Kress JP, Pohlman AS, O’Connor MF et al. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000; 342: 1471-1477 61 Barr J, Fraser GL, Puntillo K et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013; 41: 263-306 62 Martin J, Heymann A, Bäsell K et al. Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care – short version. German medical science: GMS e-Journal 2010; 8: Doc02 63 Shekar K, Roberts JA, Welch S et al. ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology 2012; 12: 29 64 Shekar K, Fraser JF, Smith MT et al. Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care 2012; 27: 741. e9-18 65 Dossow-Hanfstingl V, Deja M, Zwissler B et al. Postoperative Management – Extracorporeal Ventilatory Therapy. In: Slinger P, , ed. Principles and Practice of Anesthesia for Thoracic Surgery. New York, Dordrecht, Heidelberg, London: Springer; 2011 66 Sessler CN, Grap MJ, Brophy GM. Multidisciplinary management of sedation and analgesia in critical care. Seminars in Respiratory and Crit Care Med 2001; 22: 211-226 67 Ely EW, Inouye SK, Bernard GR et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001; 286: 2703-2710 68 Bergeron N, Dubois MJ, Dumont M et al. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Int Care Med 2001; 27: 859-864 69 Buscher H, Vaidiyanathan S, Al-Soufi S et al. Sedation practice in veno-venous extracorporeal membrane oxygenation: an international survey. ASAIO Journal 2013; 59: 636-641 70 Myers GJ, Voorhees C, Eke B et al. The effect of Diprivan (propofol) on phosphorylcholine surfaces during cardiopulmonary bypass – an in vitro investigation. Perfusion 2009; 24: 349-355 71 Patil NP, Popov AF, Lees NJ et al. Novel sequential bridge to lung transplant in an awake patient. Journal of Thorac Cardiovasc Surg 2015; 149: e2-4 72 Mohite PN, Sabashnikov A, Reed A et al. Extracorporeal Life Support in ‛Awake’ Patients as a Bridge to Lung Transplant. The Thoracic and Cardiovascular Surgeon 2015; 63: 699-705 73 Olsson KM, Simon A, Strueber M et al. Extracorporeal membrane oxygenation in nonintubated patients as bridge to lung transplantation. American Journal of Transplantation 2010; 10: 2173-2178 74 Garcia JP, Iacono A, Kon ZN et al. Ambulatory extracorporeal membrane oxygenation: a new approach for bridge-to-lung transplantation. The Journal of thoracic and cardiovascular surgery 2010; 139: e137-139 75 Hu SL, He HL, Pan C et al. The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. Critical care (London, England) 2014; 18: R109 76 Culbreth RE, Goodfellow LT. Complications of Prone Positioning During Extracorporeal Membrane Oxygenation for Respiratory Failure: A Systematic Review. Respiratory Care 2016; 61: 249-254 77 Kuhl T, Michels G, Pfister R et al. Comparison of the Avalon Dual-Lumen Cannula with Conventional Cannulation Technique for Venovenous Extracorporeal Membrane Oxygenation. The Thoracic and Cardiovascular Surgeon 2015; 63: 653-662 78 Bloomfield R, Noble DW, Sudlow A. Prone position for acute respiratory failure in adults. The Cochrane database of systematic reviews 2015; 11: CD008095 79 Oliver WC. Anticoagulation and coagulation management for ECMO. Seminars in cardiothoracic and vascular anesthesia 2009; 13: 154-175 80 Despotis GJ, Avidan MS, Hogue CW. Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. The Annals of Thoracic Surgery 2001; 72: 1821-1831 81 Skinner SC, Hirschl RB, Bartlett RH. Extracorporeal life support. Seminars in Pediatric Surgery 2006; 15: 242-250 82 Le Guennec L, Bertrand A, Laurent C et al. Diffuse cerebral microbleeds after extracorporeal membrane oxygenation support. AJRCCM 2015; 191: 594-596 83 Esper SA, Levy JH, Waters JH et al. Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion. Anesthesia and Analgesia 2014; 118: 731-743 84 Weingart C, Lubnow M, Philipp A et al. Comparison of Coagulation Parameters, Anticoagulation, and Need for Transfusion in Patients on Interventional Lung Assist or Veno-Venous Extracorporeal Membrane Oxygenation. Artificial Organs 2015; 39: 765-773 85 Laurance L et al. ELSO anticoagulation guidelines. 2014: 1-17 Im Internet: http://www.elso.org/resources/Guidelines.aspx [Stand: 24.04.2015] 86 Sohn N, Marcoux J, Mycyk T et al. The impact of different biocompatible coated cardiopulmonary bypass circuits on inflammatory response and oxidative stress. Perfusion 2009; 24: 231-237 87 HELP-ECMO pilot study. Heparin low dose protocol versus standard care in critically ill patients undergoing ECMO. Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12613001324707 88 Larsson M, Rayzman V, Nolte MW et al. A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk. Science Translational Medicine 2014; 6: 222ra17 89 Gray BW, Haft JW, Hirsch JC et al. Extracorporeal life support: experience with 2,000 patients. ASAIO Journal 2015; 61: 2-7 90 Smith A, Hardison D, Bridges B et al. Red blood cell transfusion volume and mortality among patients receiving extracorporeal membrane oxygenation. Perfusion 2013; 28: 54-60 91 Kumar T, Susheel K, Zurakowski D et al. Extracorporeal membrane oxygenation in postcardiotomy patients: factors influencing outcome. The Journal of thoracic and cardiovascular surgery 2010; 140: 330-336 92 Repessé X, Au SM, Bréchot N et al. Recombinant factor VIIa for uncontrollable bleeding in patients with extracorporeal membrane oxygenation: report on 15 cases and literature review. Crit Care (London, England) 2013; 17: R55 93 Niebler RA, Punzalan RC, Marchan M et al. Activated recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2010; 11: 98-102 94 Pieri M, Turla OG, Calabrò MG et al. A new phosphorylcholine-coated polymethylpentene oxygenator for extracorporeal membrane oxygenation: a preliminary experience. Perfusion 2013; 28: 132-137 95 Kalbhenn J, Wittau N, Schmutz A et al. Identification of acquired coagulation disorders and effects of target-controlled coagulation factor substitution on the incidence and severity of spontaneous intracranial bleeding during veno-venous ECMO therapy. Perfusion 2015; 30: 675-682 96 Lappa A, Donfrancesco S, Contento C et al. Weaning from venovenous extracorporeal membrane oxygenation without anticoagulation: is it possible?. The Annals of thoracic surgery 2012; 94: e1-e3 97 Aubron C, Cheng AC, Pilcher D et al. Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study. Critical care (London, England) 2013; 17: R73 98 Finney SJ. Extracorporeal support for patients with acute respiratory distress syndrome. European respiratory review: an official journal of the European Respiratory Society 2014; 23: 379-389 99 Cooper E, Burns J, Retter A et al. Prevalence of Venous Thrombosis Following Venovenous Extracorporeal Membrane Oxygenation in Patients With Severe Respiratory Failure. Crit Care Med 2015; 43: e581-584 100 Hemmila MR, Rowe SA, Boules TN et al. Extracorporeal life support for severe acute respiratory distress syndrome in adults. Annals of Surgery 2004; 240: 595-605 discussion 605–607 101 Noah MA, Peek GJ, Finney SJ et al. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA 2011; 306: 1659-1668 102 Mendiratta P, Tang X, Collins RT et al. Extracorporeal membrane oxygenation for respiratory failure in the elderly: a review of the Extracorporeal Life Support Organization registry. ASAIO Journal 2014; 60: 385-390 103 Schmidt M, Bailey M, Sheldrake J et al. Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score. AJRCCM 2014; 189: 1374-1382 104 Freeman CL, Bennett TD, Casper TC et al. Pediatric and neonatal extracorporeal membrane oxygenation: Does center volume impact mortality?. Critical care medicine 2014; 42: 512-519 105 Küstermann J, Gehrmann A, Kredel M et al. Akutes Lungenversagen und septische Kardiomyopathie: Erfolgreicher Einsatz der veno-venoarteriellen extrakorporalen Membranoxygenierung. Der Anaesthesist 2013; 62: 639-643 106 Forrest P, Cheong JY, Vallely MP et al. International retrieval of adults on extracorporeal membrane oxygenation support. Anaesthesia and intensive care 2011; 39: 1082-1085 107 Extracorporeal Life Support Organization. ELSO Guidelines for Training and Continuing Education of ECMO Specialists. Im Internet: http://www.elso.org/Portals/0/IGD/Archive/FileManager/97000963d6cusersshyerdocumentselsoguidelinesfortrainingandcontinuingeducationofecmospecialists.pdf [Stand: 02.04.2015] 108 Extracorporeal Life Support Organization. ELSO Guidelines for ECMO Centers. Im Internet: https://www.elso.org/Portals/0/IGD/Archive/FileManager/faf3f6a3c7cusersshyerdocumentselsoguidelinesecmocentersv1.8.pdf [Stand: 02.04.2015] 109 Mullany DV, Bull TN, Hunt W et al. Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the “learning curve” and implications for intensive care unit risk adjustment models. Critical Care and Resuscitation 2012; 14: 119-129 Supplementary Material Supplementary Material References (PDF)
